Background: Spirulina is introduced as a dietary supplement with emerging neuroprotective properties, setting the stage for its potential application in neurodegenerative conditions like dementia.

Objective: To investigate for the first time the impact of Spirulina in combination with Mediterranean Diet (MeDi) in people with mild Dementia (mD).

Methods:

• Study Design: A randomized prospective trial
• Participants: Individuals with mild dementia, with some being APOE4 carriers, a genetic risk factor for Alzheimer’s disease.
• Intervention: Participants were divided into groups, with one receiving Spirulina alongside the MeDi and another group not receiving Spirulina.
• Assessments: Neuropsychological tests were administered at baseline and after 12 months. MRI and EEG were employed in some cases to confirm diagnoses.

Results: Statistical analysis was conducted using SPSS statistical software. The study found significant improvement in cognitive function for the Spirulina group compared to the control group.

Conclusion: While long-term Spirulina supplementation in conjunction with MeDi indicated substantial cognitive benefits, the study highlights the need for further research to explore this combination's potential.

Keywords: Mild Dementia, Spirulina, Neuroprotective, Mediterranean Diet

TBA