This study was conducted as part of the research project “Medical and Social Aspects of New Psychoactive Substance Use by Youth in Uzbekistan”. The semi-structured qualitative interviews with 27 current and former NPS users in Uzbekistan, aged 16 to 36, predominantly male (19), conducted between April 2022 and December 2024 revealed a wide range of physical, psychological, social and financial consequences associated with the use of new psychoactive substances (NPS) among youth in Uzbekistan. Most respondents demonstrated general awareness of the harmful effects of NPS. In some cases, participants admitted to a lack of awareness at the onset of use or described their awareness as gradually developing. Some expressed fatalistic attitudes that downplayed the seriousness of potential consequences. Participants described a wide range of health problems associated with NPS use, including kidney and liver dysfunction, gastrointestinal problems, damage to the nasal mucosa due to intranasal administration, cardiovascular complications and negative effects on women's reproductive health. Other commonly reported symptoms included loss of appetite, insomnia, severe weight loss, chronic fatigue, facial rash, and unpleasant body odor. Social consequences, such as family breakdown, financial loss, and legal issues, were also prevalent. Despite being aware of these risks, many participants continued use due to psychological dependence, emotional instability, and lack of self- preservation instincts. The study found that 85% of participants acknowledged developing psychological dependence on NPS, with a significant number having made attempts to reduce or stop usage. The emotional and behavioral effects of NPS use were predominantly negative, with mood swings, aggression, and emotional dysregulation. The study highlights the urgent need for improved preventive measures and educational programs aimed at raising awareness about the severe risks of NPS, particularly among youth in Uzbekistan. 

Keywords: new psychoactive substances, youth, awareness, addiction, mental health, social impact, Uzbekistan.

Experienced and dedicated Psychotherapist with over twenty years of clinical experience, providing patients with advanced and effective treatment programs. Adept in assessing the condition of patients, keeping record of progress, and suggesting powerful solutions. Committed to reinforcing positive feelings and behaviors and developing mental, emotional, and behavioral goals in collaboration with the client. Expertise in behavior correction and positive behavior programming. 

Scientific researcher on topic of "Medical and social aspects of the use of new psychoactive substances among the youth of Uzbekistan". Independent researcher of the Bukhara State Medical Institute, participant of the SOLID project, in cooperation with Frankfurt University of Applied Sciences (financed by DAAD in Germany). Author of scientific articles and presenter in international conferences on new psychoactive substances and on the problems associated with HIV and NGOs in Uzbekistan.